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This is an exciting time in the treatment strategies for all hematologic malignancies; a decade ago, few would have predicted that the promises of gene-modified cell therapies would be delivered by CAR T cells directed to aggressive hematologic malignancies such as adult and pediatric B-cell ALL.
Contribution: M. Conflict-of-interest disclosure: M. All authors have sponsored research grant support from Novartis. Sign In or Create an Account.
Sign In. Skip Nav Destination Content Menu. Close Abstract. Review of clinical data with CAR T cells in hematologic malignancies. Future outlook.
Article Navigation. Maus , Marcela V. This Site. Google Scholar. Stephan A. Grupp , Stephan A. David L. Porter , David L.
Carl H. June Carl H. Blood 17 : — Article history Submitted:. Connected Content. This is a companion to: Advances in the treatment of hematologic malignancies using immunoconjugates.
This is a companion to: Immunotoxins for leukemia. Cite Icon Cite. Figure 1. View large Download PPT. Figure 2. Table 1 CAR T-cell trials in hematologic malignancies.
Signaling domain. Other genes. Cytokine support. Number of patients. Persistence peak and duration. View Large. Gene transfer.
CAR signaling domain. The online version of this article contains a data supplement. The authors thank Anne Chew and Bruce Levine for constructive comments.
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Donor-derived CDtargeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.
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