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Talk to a specialist now. PubMed Mao A, et al. Nat Commun. PubMed Meng Y, et al. Cell Death Dis. PubMed Chen D, et al.

PubMed Subramanian K, et al. Nat Microbiol. PubMed Chatterjee S et al. Cell metabolism. PubMed Fu B et al. PubMed Oliveira AC et al.

PubMed Del Alcazar D, et al. Shigatse is the second largest city in the Tibet AR, west of Lhasa. Gyantse and Qamdo are also amongst the largest.

It is governed by a People's Government, led by a Chairman. In practice, however, the Chairman is subordinate to the branch secretary of the Communist Party of China.

As a matter of convention, the Chairman has almost always been an ethnic Tibetan, while the party secretary has always been ethnically non-Tibetan.

The Tibetan economy is dominated by subsistence agriculture. Due to limited arable land, the primary occupation of the Tibetan Plateau is raising livestock, such as sheep , cattle, goats , camels , yaks , dzo , and horses.

The dogs of Tibet are twice the size of those seen in India, with large heads and hairy bodies. They are powerful animals, and are said to be able to kill a tiger.

During the day they are kept chained up, and are let loose at night to guard their masters' house. The main crops grown are barley , wheat, buckwheat , rye , potatoes, and assorted fruits and vegetables.

These include Tibetan hats, jewelry silver and gold , wooden items, clothing, quilts, fabrics, Tibetan rugs and carpets. Forty percent of the rural cash income in the Tibet Autonomous Region is derived from the harvesting of the fungus Ophiocordyceps sinensis formerly Cordyceps sinensis ; contributing at least 1.

The Qingzang railway linking the Tibet Autonomous Region to Qinghai Province was opened in , but it was controversial. In January , the Chinese government issued a report outlining the discovery of a large mineral deposit under the Tibetan Plateau.

The Chinese government sees this as a way to alleviate the nation's dependence on foreign mineral imports for its growing economy.

However, critics worry that mining these vast resources will harm Tibet's fragile ecosystem and undermine Tibetan culture. On January 15, , China announced the construction of Tibet's first expressway, the Lhasa Airport Expressway , a The project will cost 1.

From January 18—20, , a national conference on Tibet and areas inhabited by Tibetans in Sichuan, Yunnan, Gansu and Qinghai was held in China and a substantial plan to improve development of the areas was announced.

The plan calls for improvement of rural Tibetan income to national standards by and free education for all rural Tibetan children.

It is located in the western suburbs of Lhasa, the capital of the Tibet Autonomous Region. The zone has a planned area of 5.

Zone A developed a land area of 2. It is a flat zone, and has the natural conditions for good drainage.

Historically, the population of Tibet consisted of primarily ethnic Tibetans and some other ethnic groups. According to tradition the original ancestors of the Tibetan people, as represented by the six red bands in the Tibetan flag , are: the Se, Mu, Dong, Tong, Dru and Ra.

The proportion of the non-Tibetan population in Tibet is disputed. On the one hand, the Central Tibetan Administration of the Dalai Lama accuses China of actively swamping Tibet with migrants in order to alter Tibet's demographic makeup.

Religion is extremely important to the Tibetans and has a strong influence over all aspects of their lives. Bön is the indigenous religion of Tibet, but has been almost eclipsed by Tibetan Buddhism, a distinctive form of Mahayana and Vajrayana , which was introduced into Tibet from the Sanskrit Buddhist tradition of northern India.

Monks returned to monasteries across Tibet and monastic education resumed even though the number of monks imposed is strictly limited.

Tibetan Buddhism has five main traditions the suffix pa is comparable to "er" in English :. The Chinese government continued to pursue a strategy of forced assimilation and suppression of Tibetan Buddhism, as demonstrated by the laws designed to control the next reincarnation of the Dalai Lama and those of other Tibetan eminent lamas.

Monks and nuns who refused to denounce the Dalai Lama have been expelled from their monasteries, imprisoned, and tortured. The first Christians documented to have reached Tibet were the Nestorians , of whom various remains and inscriptions have been found in Tibet.

Roman Catholic Jesuits and Capuchins arrived from Europe in the 17th and 18th centuries. These included the Jesuit Father Ippolito Desideri , —, who gained a deep knowledge of Tibetan culture, language and Buddhism, and various Capuchins in —, — and —, [] Christianity was used by some Tibetan monarchs and their courts and the Karmapa sect lamas to counterbalance the influence of the Gelugpa sect in the 17th century until in when all the missionaries were expelled at the lama's insistence.

Famous earlier missionaries include James O. Proselytising has been illegal in China since But as of [update] , many Christian missionaries were reported to be active in Tibet with the tacit approval of Chinese authorities, who view the missionaries as a counterforce to Tibetan Buddhism or as a boon to the local economy.

Muslims have been living in Tibet since as early as the 8th or 9th century. In Tibetan cities, there are small communities of Muslims , known as Kachee Kache , who trace their origin to immigrants from three main regions: Kashmir Kachee Yul in ancient Tibetan , Ladakh and the Central Asian Turkic countries.

Islamic influence in Tibet also came from Persia. Which became main cause of the cultural separation of the people of Baltistan from the mainstream Tibet.

After a group of Tibetan Muslims made a case for Indian nationality based on their historic roots to Kashmir and the Indian government declared all Tibetan Muslims Indian citizens later on that year.

There is also a well established Chinese Muslim community gya kachee , which traces its ancestry back to the Hui ethnic group of China. Tibetan representations of art are intrinsically bound with Tibetan Buddhism and commonly depict deities or variations of Buddha in various forms from bronze Buddhist statues and shrines, to highly colorful thangka paintings and mandalas.

Tibetan architecture contains Chinese and Indian influences, and reflects a deeply Buddhist approach. The Buddhist wheel , along with two dragons, can be seen on nearly every Gompa in Tibet.

The design of the Tibetan Chörtens can vary, from roundish walls in Kham to squarish, four-sided walls in Ladakh. The most distinctive feature of Tibetan architecture is that many of the houses and monasteries are built on elevated, sunny sites facing the south, and are often made out of a mixture of rocks, wood, cement and earth.

Little fuel is available for heat or lighting, so flat roofs are built to conserve heat, and multiple windows are constructed to let in sunlight.

Walls are usually sloped inwards at 10 degrees as a precaution against the frequent earthquakes in this mountainous area.

Standing at metres feet in height and metres 1, feet in width, the Potala Palace is the most important example of Tibetan architecture.

Formerly the residence of the Dalai Lama , it contains over one thousand rooms within thirteen stories, and houses portraits of the past Dalai Lamas and statues of the Buddha.

It is divided between the outer White Palace, which serves as the administrative quarters, and the inner Red Quarters, which houses the assembly hall of the Lamas, chapels, 10, shrines, and a vast library of Buddhist scriptures.

The music of Tibet reflects the cultural heritage of the trans-Himalayan region, centered in Tibet but also known wherever ethnic Tibetan groups are found in India, Bhutan , Nepal and further abroad.

First and foremost Tibetan music is religious music , reflecting the profound influence of Tibetan Buddhism on the culture. Tibetan music often involves chanting in Tibetan or Sanskrit , as an integral part of the religion.

These chants are complex, often recitations of sacred texts or in celebration of various festivals. Yang chanting, performed without metrical timing, is accompanied by resonant drums and low, sustained syllables.

Other styles include those unique to the various schools of Tibetan Buddhism, such as the classical music of the popular Gelugpa school, and the romantic music of the Nyingmapa , Sakyapa and Kagyupa schools.

Nangma dance music is especially popular in the karaoke bars of the urban center of Tibet, Lhasa. Another form of popular music is the classical gar style, which is performed at rituals and ceremonies.

Lu are a type of songs that feature glottal vibrations and high pitches. There are also epic bards who sing of Gesar , who is a hero to ethnic Tibetans.

Tibet has various festivals, many for worshipping the Buddha, [] that take place throughout the year.

Losar is the Tibetan New Year Festival. Preparations for the festive event are manifested by special offerings to family shrine deities, painted doors with religious symbols, and other painstaking jobs done to prepare for the event.

Tibetans eat Guthuk barley noodle soup with filling on New Year's Eve with their families. The Monlam Prayer Festival follows it in the first month of the Tibetan calendar , falling between the fourth and the eleventh days of the first Tibetan month.

It involves dancing and participating in sports events, as well as sharing picnics. The most important crop in Tibet is barley , and dough made from barley flour—called tsampa —is the staple food of Tibet.

This is either rolled into noodles or made into steamed dumplings called momos. Meat dishes are likely to be yak , goat, or mutton , often dried, or cooked into a spicy stew with potatoes.

Mustard seed is cultivated in Tibet, and therefore features heavily in its cuisine. Yak yogurt , butter and cheese are frequently eaten, and well-prepared yogurt is considered something of a prestige item.

Butter tea is a very popular drink. From Wikipedia, the free encyclopedia. Plateau region in Asia. This article is about historical ethno-cultural concept of Tibet.

For the current administration, see Tibet Autonomous Region. For other uses, see Tibet disambiguation. Main article: Definitions of Tibet.

Main article: Standard Tibetan. PubMed LM S, et al. Cell Rep. PubMed Mackroth M, et al. PLoS Pathog. PubMed Lu Y, et al. Br J Pharmacol.

PubMed Cao Y, et al. Nat Commun. PubMed Linehan JL et al. PubMed Romain Bouziat et al. PubMed Kelsey E Sivick et al.

Cell reports. For Research Use Only. Not for use in diagnostic or therapeutic procedures. Although not required, these products are manufactured in accordance with Good Manufacturing Practices.

Analyte Specific Reagent. Analytical and performance characteristics are not established. Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.

Product Details Recommended Assay References. Description The 4B10 monoclonal antibody specifically binds to human and mouse T-bet.

View reference Peng SL.

This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for. Tibet (/ t ɪ ˈ b ɛ t / (); Tibetan: བོད་, Lhasa dialect: [/pʰøː˨˧˩/]; Chinese: 西藏; pinyin: Xīzàng) is a region in East Asia covering much of the Tibetan Plateau spanning about million km 2. Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoid development controlling the production of the cytokine IFN-γ. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet, a T-box transcription factor, is expressed in CD4+ T lymphocytes committed to Th1 T-cell development and may participate in immunoglobulin class switching in B lymphocytes. Demystifying Tibet: unlocking the secrets of the land of the snows. Retrieved August 26, J Leukoc Biol. Retrieved April 16, T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. Moscow: Russian Acad. The Dalai Lama had 3 Monatsregel strong following as many people from Tibet looked at him not Wer überträgt Euro League as their political leader, but as their spiritual leader. There is no leader. Tibet: Its History, Religion and Masters 2021. Archived from Tbet original on April 1, PubMed Cao Y, et al.

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